PU¶PubMed·Journal article·Research (general)·7w agoGadd45a knockout alleviates cisplatin-induced hearing loss by inhibiting CXCL family protein expressionThis is a mouse study identifying a potential molecular target for preventing cisplatin-related hearing damage; no actionable change in clinical practice is warranted at this stage.＋Save
PU¶PubMed·Journal article·Tinnitus·8w agoEfficacy of non-invasive neuromodulation for chronic tinnitus: a systematic review and meta-analysis of randomized controlled trialsFindings may support adding non-invasive neuromodulation as an adjunct for chronic tinnitus, but clinicians should await the full paper's effect-size and safety data before changing protocols.＋Save
PU¶PubMed·Journal article·Tinnitus·8w agoTransverse sinus dominance predicts outcome after venous sinus stenting for pulsatile tinnitusTransverse sinus dominance may help predict incomplete relief after venous sinus stenting for pulsatile tinnitus; audiologists should be aware of this radiological predictor when co-managing or counselling stenting candidates, though surgical decision-making remains with the...＋Save
PU¶PubMed·Journal article·Research (general)·8w agoPeripheral CD4 T-Cell State Remodeling in Migraine Revealed by Single-Cell RNA SequencingUnderstanding the neuroimmune basis of migraine may eventually inform treatment of vestibular migraine, a condition routinely encountered in audiology and otoneurology clinics.＋Save
PU✚PubMed·Clinical trial·Vestibular·8w agoVirtual Reality-Based Vestibular Rehabilitation for Vestibular Migraine: A Randomized TrialIf VR-augmented vestibular rehabilitation shows significantly better outcomes than home-based therapy alone, clinicians managing vestibular migraine patients should consider VR as an adjunct — but clinical adoption should await the full published results and effect-size...＋Save
PU¶PubMed·Journal article·Tinnitus·8w agoChirp-Evoked Electrocochleography and Speech-in-Noise Performance in Normal-Hearing Individuals With TinnitusIf chirp-evoked electrocochleography findings support cochlear synaptopathy as an underlying mechanism linking tinnitus and speech-in-noise difficulty in normal-hearing individuals, clinicians should consider synaptopathy screening in tinnitus patients who complain of poor...＋Save
PU¶PubMed·Journal article·Tinnitus·8w agoBiomarkers of Subjective Tinnitus Presence and Clinical Burden: A Systematic ReviewIdentifying reliable objective biomarkers for tinnitus could transform diagnosis, patient stratification, and treatment-outcome measurement, addressing a longstanding gap in tinnitus clinical research.＋Save
PU¶PubMed·Journal article·Tinnitus·8w agoAvatar therapy for bothersome tinnitus using an augmented reality mobile application: a pilot feasibility studyDigital and AR-based tinnitus interventions are an emerging frontier; this feasibility work helps establish whether avatar therapy translated into a mobile app is viable enough to test in a powered clinical trial.＋Save
PU¶PubMed·Journal article·Clinical audiology·8w agoHyperacusis scores and listening characteristics: Extended high-frequency audiograms from a young population without tinnitus and with low noise exposureUnderstanding how extended high-frequency hearing relates to hyperacusis sensitivity in young, noise-naïve adults may help establish baseline norms and early markers before overt auditory damage develops.＋Save
PU¶PubMed·Journal article·Tinnitus·8w agoSerum Levels of Prestin, Otoferlin, Connexin 26, and Stereocilin: A Biomarker Approach to TinnitusThis biomarker study is preliminary; serum prestin, otoferlin, connexin 26, and stereocilin are not yet validated for clinical tinnitus diagnosis and no practice change is warranted at this stage.＋Save
PU¶PubMed·Journal article·Vestibular·8w agoMolecular Biomarkers in Meniere's Disease: A Scoping Review of Current EvidenceThis scoping review maps existing evidence on molecular biomarkers in Meniere's disease; no specific biomarker is yet ready for routine clinical use, so no practice change is indicated.＋Save
PU¶PubMed·Journal article·Tinnitus·8w agoCase Report: Repeated courses of low-frequency rTMS for refractory tinnitus: an N-of-1 studyRefractory tinnitus remains one of audiology's hardest therapeutic challenges, and this report adds a data point on whether repeated rTMS courses sustain benefit, though far larger trials are needed.＋Save
PU¶PubMed·Journal article·Tinnitus·2mo agoAsymmetry of vestibular pathways predicts upper-brainstem auditory imbalance in subjective somatosensory tinnitus: A tract-specific chronological reorganization modelThis mechanistic model linking vestibular pathway asymmetry to somatic tinnitus is preliminary and hypothesis-generating; no change to clinical assessment or treatment protocols is warranted based on this single study.＋Save
PU¶PubMed·Journal article·Cochlear implants·2mo agoA Nordic cohort study on cochlear implants and binaural hearing in single-sided deafnessCohort-level outcomes data from a Nordic population support cochlear implantation as a treatment option for adult single-sided deafness, reinforcing existing evidence — audiologists should review specific outcome metrics once the full paper is available to refine candidacy...＋Save
PU¶PubMed·Journal article·Vestibular·2mo agoZDHHC5 may regulate the function of NKT cells and the immune response in Meniere's diseaseIdentifying a genetic regulator of immune activity in Ménière's disease advances the understanding of its poorly characterized autoimmune mechanisms, potentially opening new therapeutic targets.＋Save
PU¶PubMed·Journal article·Tinnitus·2mo agoTargeted inhibition of the BDNF/AKT/mTOR pathway in the inferior colliculus ameliorates salicylate-induced tinnitus in ratsIdentifying the BDNF/AKT/mTOR pathway as a contributor to tinnitus opens a new molecular target avenue that could eventually lead to the first pharmacological treatments for tinnitus in humans.＋Save
PU¶PubMed·Journal article·Tinnitus·2mo agoAudiologic Characteristics of Military Service Members and Veterans With and Without Tinnitus and Comorbid Posttraumatic Stress DisorderAudiologists working with military and veteran populations should be aware that comorbid PTSD may be associated with distinct audiologic profiles in tinnitus patients, suggesting the need for integrated screening and interdisciplinary care pathways.＋Save
PU¶PubMed·Journal article·Tinnitus·2mo agoClinical and Demographic Characterization of Tinnitus and Factors Associated With Discomfort in a Large Sample of Patients Evaluated in Bogota, ColombiaClinicians in Latin American settings and globally may reference this large-sample characterization to benchmark local tinnitus populations, though findings must be replicated before changing assessment or management protocols.＋Save
PU¶PubMed·Journal article·Tinnitus·2mo agoPsychological Correlates of Tinnitus Handicap: Associations with Personality Traits and Emotional DistressAudiologists managing tinnitus patients should routinely screen for emotional distress and personality-linked vulnerability, as these psychological factors appear to independently predict tinnitus-related handicap and may warrant referral for psychological support.＋Save
PU¶PubMed·Journal article·Research (general)·2mo agoNeurovascular-Immune Biomarkers in Ménière Disease: Insights From High-Throughput ProteomicsIdentifying reliable biomarkers for Ménière disease could eventually enable objective diagnosis and targeted therapies for a condition currently managed by symptom control alone.＋Save
PU¶PubMed·Journal article·Research (general)·2mo agoSynaptic zinc plasticity shapes adaptive and maladaptive cortical plasticity following cochlear injuryIdentifying synaptic zinc plasticity as a driver of both adaptive and maladaptive auditory cortex reorganization after cochlear injury opens a potential new molecular target for future tinnitus and hearing-loss therapies.＋Save
PU¶PubMed·Journal article·Tinnitus·2mo agoInvestigation of Hyperacusis in Patients with TinnitusAudiologists managing tinnitus patients should routinely screen for hyperacusis, as this study suggests meaningful co-occurrence; however, practice protocols should await replication in larger, well-controlled studies.＋Save
RNID·Blog·Public health & policy·2mo agoDon’t Lose the MusicMusic-induced noise exposure is a preventable and under-addressed cause of hearing loss, and public advocacy content from organisations like RNID can support audiologists' patient education efforts.＋Save
PU¶PubMed·Journal article·Research (general)·2mo agoIn-Ear Transcranial Alternating Current Stimulation: Auditory Perception and Side Effects Depend on Electrode Montage, Frequency, and Direct Current-OffsetUnderstanding how electrode placement, frequency, and DC-offset shape both the perceptual and safety profile of in-ear tACS is a necessary step toward developing cochlear neuromodulation as a potential tinnitus or hearing rehabilitation therapy.＋Save
PU¶PubMed·Journal article·Tinnitus·2mo agoInflammatory Signatures of Tinnitus in Patients and MiceIdentifying specific inflammatory markers shared across human tinnitus patients and animal models opens a credible biological pathway for future drug or immunotherapy targets, potentially reshaping how tinnitus is treated.＋Save
PU¶PubMed·Journal article·Tinnitus·2mo agoEEG microstates and dynamic functional connectivity reveal stage-specific brain networks in subjective tinnitusIdentifying stage-specific brain network signatures in tinnitus could eventually guide targeted neurostimulation or biofeedback therapies, moving tinnitus management beyond symptom masking.＋Save
PU¶PubMed·Journal article·Tinnitus·2mo agoMedial Geniculate Body Deep Brain Stimulation for Refractory Tinnitus: Neurophysiological Rationale and Translational Neuromodulation PerspectivesFor the estimated millions with treatment-refractory tinnitus, a neurophysiologically grounded neuromodulation target could open an entirely new category of intervention if translational research advances.＋Save
Hearing Practitioner Australia·Journal article·Public health & policy·2mo agoHearing loss, tinnitus appear earlier and are more severe in veterans, study findsAudiologists seeing veteran patients should anticipate earlier onset and greater severity of both hearing loss and tinnitus compared to civilian norms, and may need to adjust screening thresholds and rehabilitation planning accordingly for this population.＋Save
Hearing Health Matters·Press release·Tinnitus·2mo agoSonorous Neurovascular Enrolls First Canadian Patient in B-SILENT Pulsatile Tinnitus StudyPulsatile tinnitus linked to narrowed brain blood vessels (cerebral venous sinus stenosis) has very limited treatment options, and a dedicated implant trial could open a new interventional pathway if results are positive.＋Save
