Hyperacusis is a troubling loudness hypersensitivity disorder occasionally involving pain around ear and face. The neural origins of hyperacusis and conditions that evoke it are poorly understood. To gain insights into the neural mechanisms that might give rise to hyperacusis, a pharmacovigilance analysis was conducted on 3833 case reports in which hyperacusis was listed as a drug-induced adverse event in the United...
Audiologists should be aware that certain drug classes may trigger or worsen hyperacusis; this review may prompt more careful medication history-taking in hyperacusis patients, but specific clinical protocols await further research.
Identifying drug-induced hyperacusis expands the differential for a poorly understood and underdiagnosed condition, potentially opening new avenues for prevention and treatment.
- 01Review identifies drug candidates that may induce hyperacusis, a loudness hypersensitivity disorder.
- 02Examines neural mechanisms underlying drug-induced loudness hypersensitivity.
- 03Periauricular (around-the-ear) pain is highlighted as a potential symptom in affected patients.
- 04Triggering conditions and patient vulnerability factors are explored.
- 05Findings are based on a review of existing literature, not a new clinical trial.
Certain drug candidates can induce hyperacusis.
studypartially supportedHyperacusis induced by drugs has identifiable neural origins.
studyunclear- PMID
- 42143865
- DOI
- 10.1016/j.heares.2026.109673.
- Journal
- Hearing Research
- Publication type
- review
- Evidence level
- 5
- Population
- Literature review; no direct patient population
- Intervention
- Drug candidates potentially inducing hyperacusis
Primary outcomes
Identification of drug candidates associated with hyperacusis; Neural mechanisms underlying drug-induced hyperacusis; Triggering conditions for hyperacusis onset