Chronic subjective tinnitus affects 15-20% of adults globally, with 3-5% experiencing severe quality-of-life impairment. Sound therapy (ST) is a core intervention, but its neuromodulatory mechanisms remain incompletely characterized due to the lack of objective biomarkers.

This meta-analysis provides neurophysiological evidence supporting sound therapy's effect on brain activity in chronic tinnitus, but clinicians should interpret EEG outcomes cautiously as surrogate markers until they are linked to validated patient-reported symptom improvement.

Objective EEG biomarkers for tinnitus treatment response could help clinicians select and monitor sound therapy interventions, advancing the field beyond purely subjective outcome measures.

1. 01Meta-analysis of EEG studies evaluates neurophysiological effects of sound therapy on chronic subjective tinnitus.
2. 02