Auditory function in pediatric idiopathic nephrotic syndrome: Correlations with disease severity and corticosteroid burden

To evaluate the prevalence and nature of hearing dysfunction in children with idiopathic nephrotic syndrome (INS) using objective audiological modalities, and to correlate findings with disease status, cumulative corticosteroid dose, and relapse frequency.

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Audiologists seeing pediatric patients with idiopathic nephrotic syndrome should be aware of a potential association between disease severity, corticosteroid burden, and hearing dysfunction — routine audiological monitoring in this population may be warranted, pending replication in larger prospective studies.

This study highlights an underrecognized auditory risk in a common pediatric kidney disease, potentially expanding the populations audiologists screen for drug- and disease-related hearing changes.

1. 01Cross-sectional study examining hearing loss prevalence in children with idiopathic nephrotic syndrome.
2. 02Audiological findings were correlated with both disease severity markers and cumulative corticosteroid exposure.
3. 03Objective audiological measures (likely including audiometry and/or OAEs) were used.
4. 04Findings suggest corticosteroid burden may contribute to hearing dysfunction in this pediatric group.
5. 05Study design is cross-sectional, limiting causal inference.

PMID

42561621

DOI

10.1016/j.ijporl.2026.112933.

Journal

International Journal of Pediatric Otorhinolaryngology

Publication type

research_article

Evidence level

3

Population

Pediatric patients with idiopathic nephrotic syndrome

Intervention

Objective audiological assessment (hearing function evaluation)