Giant skull base collision tumors in NF2-related schwannomatosis: longitudinal outcomes of planned selective resection

OBJECTIVES: Giant skull base collision tumors in neurofibromatosis type 2-related schwannomatosis (NF2-SWN) pose a complex surgical challenge in young patients with lifelong tumor burden. Gross total resection is often impossible without severe neurological morbidity, and data on operative timing and durability are limited....

Planned selective (partial) resection may be a viable long-term strategy for giant skull base collision tumors in NF2-related schwannomatosis, but this is a specialized neurosurgical finding; audiologists managing these patients should be aware of the surgical philosophy but no change to audiology practice is indicated at this time.

Understanding long-term surgical outcomes in NF2-related schwannomatosis is critical for audiology and neuro-oncology teams co-managing young patients facing lifelong tumor burden and progressive hearing loss.

1. 01Study focuses on giant skull base collision tumors in NF2-related schwannomatosis (NF2-RS), a rare genetic tumor disorder.
2. 02Planned selective (intentionally incomplete) resection was the primary surgical strategy evaluated.
3. 03Longitudinal outcomes data were collected, providing insight into long-term tumor control and nerve preservation.
4. 04NF2-RS typically affects young patients who face a lifetime of recurrent tumor management.
5. 05Published in the Journal of Neuro-Oncology (DOI: 10.1007/s11060-026-05641-0).

PMID

42257800

DOI

10.1007/s11060-026-05641-0.

Journal

Journal of Neuro-Oncology

Publication type

research_article

Evidence level

4

Population

Young patients with NF2-related schwannomatosis presenting with giant skull base collision tumors

Intervention

Planned selective (intentionally incomplete) surgical resection of giant skull base collision tumors