Giant skull base collision tumors in NF2-related schwannomatosis: longitudinal outcomes of planned selective resection

OBJECTIVES: Giant skull base collision tumors in neurofibromatosis type 2-related schwannomatosis (NF2-SWN) pose a complex surgical challenge in young patients with lifelong tumor burden. Gross total resection is often impossible without severe neurological morbidity, and data on operative timing and durability are limited....

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Planned selective (partial) resection may be a viable long-term strategy for giant skull base collision tumors in NF2-related schwannomatosis, but this is a specialized neurosurgical finding; audiologists managing these patients should be aware of the surgical philosophy but no change to audiology practice is indicated at this time.

Understanding long-term surgical outcomes in NF2-related schwannomatosis is critical for audiology and neuro-oncology teams co-managing young patients facing lifelong tumor burden and progressive hearing loss.

1. 01Study focuses on giant skull base collision tumors in NF2-related schwannomatosis (NF2-RS), a rare genetic tumor disorder.
2. 02Planned selective (intentionally incomplete) resection was the primary surgical strategy evaluated.
3. 03Longitudinal outcomes data were collected, providing insight into long-term tumor control and nerve preservation.
4. 04NF2-RS typically affects young patients who face a lifetime of recurrent tumor management.
5. 05Published in the Journal of Neuro-Oncology (DOI: 10.1007/s11060-026-05641-0).

PMID

42257800

DOI

10.1007/s11060-026-05641-0.

Journal

Journal of Neuro-Oncology

Publication type

research_article

Evidence level

4

Population

Young patients with NF2-related schwannomatosis presenting with giant skull base collision tumors

Intervention

Planned selective (intentionally incomplete) surgical resection of giant skull base collision tumors