Ménière's disease is a prevalent chronic condition that triggers a range of vestibular and auditory symptoms. Despite significant advances in mechanisms such as genetic susceptibility, immunity, and allergy, a clear understanding of its core pathophysiology has not been established, and a consistent theoretical framework is still lacking....
No actionable clinical change; this is a review of basic research mechanisms and animal models, not a clinical trial or guideline update.
A comprehensive review of Ménière's disease mechanisms and animal models provides a research roadmap that could accelerate development of targeted therapies for this poorly understood and difficult-to-treat condition.
- 01Review covers current understanding of genetic, immune, and anatomical factors underlying Ménière's disease.
- 02Surveys animal models used to replicate Ménière's disease symptoms and pathology.
- 03Genetic susceptibility is highlighted as an emerging area of interest.
- 04Published in Genes & Diseases, a peer-reviewed genetics and disease journal.
- 05No new clinical data are presented; findings are synthesised from existing literature.
Genetic susceptibility plays a role in the development of Ménière's disease.
studypartially supported- PMID
- 42253756
- DOI
- 10.1016/j.gendis.2025.102022.
- Journal
- Genes & Diseases
- Publication type
- review
- Evidence level
- 1a
- Population
- Literature on Ménière's disease mechanisms and animal models
- Intervention
- Review of genetic susceptibility factors and animal models
Primary outcomes
Mechanistic pathways of Ménière's disease; Utility of existing animal models