Cerebrospinal Fluid miRNA Profiling as a Potential Liquid Biopsy for Vestibular Schwannomas

/Objectives : This study aimed to identify a characteristic miRNA expression profile in the CSF of patients diagnosed with vestibular schwannoma and evaluate its potential for tumor assessment. Methods : In this prospective study, 17 CSF and corresponding tumor samples (seven small tumors-SVS and 10 large tumors-LVS) were collected from patients operated on for VS in a Tertiary Academic Center....

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No actionable change for current clinical practice—CSF miRNA profiling for vestibular schwannoma is investigational and not yet validated for clinical use, but warrants monitoring as a potential future non-invasive monitoring tool.

A validated CSF miRNA liquid biopsy for vestibular schwannoma could eventually replace or supplement serial MRI surveillance, reducing cost and radiation exposure for the large population of patients managed on a 'watch and wait' protocol.

1. 01Vestibular schwannoma patients showed a characteristic miRNA expression profile in cerebrospinal fluid (CSF).
2. 02CSF miRNA profiling is being explored as a 'liquid biopsy'—a minimally invasive tumor assessment tool.
3. 03If validated, this approach could supplement or reduce reliance on serial MRI for tumor monitoring.
4. 04The study is preliminary; clinical application requires further validation in larger, independent cohorts.
5. 05Directly relevant to audiologists involved in acoustic neuroma monitoring and counseling.

PMID

42776741

DOI

10.3390/ncrna12050035.

Journal

Non-Coding RNA

Publication type

research_article

Evidence level

4

Population

Patients with vestibular schwannoma (acoustic neuroma)

Intervention

CSF miRNA expression profiling