Meniere's disease is a complex chronic inner ear condition that is characterized by vertigo, tinnitus, aural fullness, and progressive hearing loss. Currently, diagnostic strategies remain symptom-driven, and treatments focus on management of discrete episodes rather than targeting underlying pathophysiology....
✦ The floor
Discussion
Signed responses from readers of the wire.
This scoping review maps existing evidence on molecular biomarkers in Meniere's disease; no specific biomarker is yet ready for routine clinical use, so no practice change is indicated.
Identifying reliable molecular biomarkers for Meniere's disease could enable earlier diagnosis, better disease monitoring, and more targeted therapies for a condition that remains poorly understood.
- 01Scoping review design surveys the breadth of molecular biomarker research in Meniere's disease without meta-analytic pooling.
- 02Covers biomarkers across multiple molecular categories (e.g., inflammatory, autoimmune, genetic markers).
- 03Published in Otolaryngology–Head and Neck Surgery (doi: 10.1002/ohn.70401).
- 04Highlights current evidence gaps and heterogeneity across studies.
- 05No single validated biomarker for Meniere's disease has emerged from the literature reviewed.
Molecular biomarkers for Meniere's disease have been investigated but none are currently validated for clinical use.
studysupportedA scoping review design captures the current landscape of Meniere's disease biomarker evidence.
studysupported- PMID
- 42606302
- DOI
- 10.1002/ohn.70401.
- Journal
- Otolaryngology–Head and Neck Surgery
- Publication type
- review
- Evidence level
- 2a
- Population
- Studies of patients with Meniere's disease investigated for molecular biomarkers
- Intervention
- Molecular biomarker assessment in Meniere's disease
Primary outcomes
Catalogue of molecular biomarkers investigated in Meniere's disease; Identification of evidence gaps