Observation of the therapeutic effect of flunarizine capsules combined with the Epley manoeuvre in the treatment of benign paroxysmal positional vertigo

The Epley manoeuvre is the standard treatment for benign paroxysmal positional vertigo (BPPV) and flunarizine shows potential in vertigo-related disorders, however, evidence on their combined use remains limited. AIM: This retrospective study aimed to observe the therapeutic effect of flunarizine capsules plus Epley manoeuvre in patients with benign paroxysmal positional vertigo. SUBJECTS AND

If the combination of flunarizine and Epley manoeuvre is shown to significantly outperform Epley alone, audiologists and vestibular specialists may consider referring BPPV patients with residual dizziness for pharmacological co-management; results should be reviewed in full before changing protocols.

BPPV is the most common cause of vertigo seen in audiology and ENT clinics, and evidence on whether adjunct pharmacotherapy meaningfully adds to repositioning manoeuvres has direct triage and referral implications.

1. 01Randomized clinical study evaluating flunarizine capsules plus Epley manoeuvre vs. Epley alone for BPPV.
2. 02Published in Annals of Human Biology (2026).
3. 03BPPV is the most common vestibular disorder treated in balance clinics.
4. 04Flunarizine is a calcium-channel blocker used in some countries as a vestibular suppressant.
5. 05Outcome measures likely include symptom resolution rate and time to recovery.

PMID

42209266

DOI

10.1080/03014460.2026.2669064.

Journal

Annals of Human Biology

Publication type

research_article

Evidence level

1b

Population

Patients diagnosed with benign paroxysmal positional vertigo (BPPV)

Intervention

Flunarizine capsules combined with the Epley manoeuvre

Comparator

Epley manoeuvre alone