Hereditary vestibular dysfunctions (HVDs) are a group of diseases caused by genetic mutations, characterized by congenital or progressive vestibular dysfunction, often accompanied by hearing loss or other systemic damages. These diseases are divided into syndromic (e.g., Usher syndrome, CHARGE syndrome) and non-syndromic types, involving mutations in key genes such as MYO7A, COCH, SLC26A4, TMC1, etc....
No actionable change — this is a preclinical review of mouse models; findings have not yet been translated into clinical practice for hereditary vestibular dysfunction.
Mapping the genetic and mechanistic landscape of hereditary vestibular dysfunction in mouse models is a critical step toward developing targeted therapies for patients with inherited balance disorders.
- 01Reviews mouse models used to study hereditary vestibular dysfunctions (HVDs) caused by genetic mutations.
- 02Covers both congenital (present from birth) and progressive forms of vestibular dysfunction.
- 03Summarizes translational research progress — i.e., efforts to move findings from animal models toward human treatments.
- 04Highlights the genetic mutations implicated in HVDs and their inner-ear mechanisms.
- 05Identifies gaps between preclinical mouse data and clinical application in humans.
Mouse models are useful tools for studying hereditary vestibular dysfunctions caused by genetic mutations.
studysupportedTranslational research using mouse models is progressing toward therapies for hereditary vestibular dysfunction.
opinionpartially supported- PMID
- 42216666
- DOI
- 10.1177/09574271261453788.
- Journal
- International Journal of Audiology
- Publication type
- review
- Evidence level
- 5
- Population
- Not applicable — review of mouse models of hereditary vestibular dysfunction
- Intervention
- Review of genetic mouse models of hereditary vestibular dysfunction
Primary outcomes
Characterization of mouse models relevant to hereditary vestibular dysfunction; Summary of translational research progress toward human therapies