Retraction notice to "molecular mechanism of Rolupram reducing neuroinflammation in noise induced tinnitus mice through TLR4/NF kB/NLRP3 protein/caspase-1/IL-1 beta signaling pathway" [international journal of biological macromolecules 278 (2024) 134987]

✦ Clinical Takeaway ✦

No actionable change — the retracted study on Rolupram for noise-induced tinnitus should be disregarded entirely; it must not be cited or used to inform any clinical or research decisions.

✦ Why It Matters ✦

Retraction of a tinnitus neuroinflammation study removes a potentially flawed data point from the literature and serves as a reminder to verify citation integrity in a field where preclinical animal studies are heavily relied upon.

✦ Key Points ✦

01Retraction issued for a 2024 paper on Rolupram and neuroinflammation in noise-induced tinnitus mice.
02Original study claimed Rolupram acted via TLR4/NF-κB/NLRP3/caspase-1/IL-1β pathway.
03Published in International Journal of Biological Macromolecules; reason for retraction not specified in the notice.
04Retracted work should not be cited or built upon in future tinnitus research.
05Highlights ongoing concerns about research integrity in preclinical hearing science.

✦ Claims & Evidence ✦

ClaimEvidenceSupport

The 2024 article claiming Rolupram reduces neuroinflammation in noise-induced tinnitus mice via TLR4/NF-κB/NLRP3/caspase-1/IL-1β signaling has been formally retracted.

guidelinesupported

✦ Research metadata ✦

PMID: 42481331
DOI: 10.1016/j.ijbiomac.2026.153433.

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