Pregnancy and Peripartum Multidisciplinary Management in Wolfram Syndrome Type 1: A Case Report

/Objectives: Wolfram syndrome type 1 (WS1) is a rare, progressive, multisystem neurodegenerative disorder characterized by diabetes mellitus, optic atrophy, diabetes insipidus, and sensorineural hearing loss. As survival has improved, an increasing number of affected women are reaching reproductive age. However, evidence on pregnancy and peripartum management in WS1 remains scarce, and practical guidance is limited....

This single case report offers no generalizable guidance for audiology practice; audiologists encountering Wolfram Syndrome patients should continue coordinating with neurology and genetics, but no practice change is supported by a single case.

Wolfram Syndrome Type 1 is a rare but serious cause of progressive hearing loss, and documenting pregnancy management expands the limited clinical literature on this condition.

1. 01Case report describes pregnancy and peripartum care in a patient with Wolfram Syndrome Type 1 (WS1).
2. 02WS1 is a rare neurodegenerative disorder featuring hearing loss, vision loss, diabetes insipidus, and diabetes mellitus.
3. 03Multidisciplinary team management was central to the described approach.
4. 04Published in the journal Diagnostics (MDPI); PMID 42072744.
5. 05Evidence level is very low (single case report); findings are not generalizable.

PMID

42072744

DOI

10.3390/diagnostics16081117.

Journal

Diagnostics

Publication type

case_report

Evidence level

4

Sample size

1

Population

Single pregnant patient with Wolfram Syndrome Type 1

Intervention

Multidisciplinary management during pregnancy and peripartum period