Multiple inflammatory cytokines correlate with the vestibular and oculomotor dysfunction in Fabry disease: a prospective, longitudinal study

OBJECTIVES: Vestibular and oculomotor abnormalities have been widely identified in Fabry disease (FD), with inflammation potentially playing an important role. We aim to investigate the expression of inflammatory cytokines (ICs) in FD patients and their relationship with the vestibular/oculomotor dysfunctions.

Audiologists and vestibular specialists managing Fabry disease patients should be aware that inflammatory cytokine levels may correlate with vestibular and oculomotor dysfunction, though this does not yet change vestibular assessment or treatment protocols.

Identifying inflammation as a driver of vestibular and oculomotor dysfunction in Fabry disease opens potential avenues for monitoring disease progression and targeting anti-inflammatory therapies.

1. 01Prospective longitudinal study links multiple inflammatory cytokines to vestibular and oculomotor dysfunction in Fabry disease.
2. 02Fabry disease is a rare lysosomal storage disorder with multisystem involvement including the inner ear and balance system.
3. 03Findings suggest inflammation — not just lipid accumulation — contributes to balance and eye movement problems.
4. 04Published in Frontiers in Immunology; peer-reviewed prospective design strengthens reliability.
5. 05Results may inform future biomarker-based monitoring strategies in Fabry disease management.

PMID

42079593

DOI

10.3389/fimmu.2026.1658002.

Journal

Frontiers in Immunology

Publication type

research_article

Evidence level

2b

Population

Patients with confirmed Fabry disease followed longitudinally

Intervention

Measurement of inflammatory cytokine levels in Fabry disease patients