Quantitative pupillometry as a marker of autonomic dysregulation in vestibular migraine

Vestibular migraine (VM) has been associated with altered central sensory processing; however, objective measures of autonomic involvement remain insufficiently characterized. Quantitative pupillometry enables standardized assessment of both static and dynamic pupil responses. This study compared pupillary parameters between patients with VM and healthy controls under controlled illumination conditions.

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Preliminary evidence that quantitative pupillometry may detect autonomic dysregulation in vestibular migraine patients; not yet ready for routine clinical adoption — further validation in larger studies is needed.

An objective, non-invasive autonomic biomarker for vestibular migraine could improve diagnostic precision and open new therapeutic targets in a condition that is frequently underdiagnosed.

1. 01Quantitative pupillometry was evaluated as a non-invasive marker of autonomic nervous system dysfunction.
2. 02Study population: patients with vestibular migraine, a condition causing episodic dizziness linked to migraines.
3. 03Addresses a gap — autonomic involvement in vestibular migraine has been difficult to measure objectively.
4. 04Findings are preliminary; sample size and study design details are not fully available from the abstract.
5. 05Could inform future diagnostic protocols if validated in larger, controlled trials.

PMID

42548108

DOI

10.22514/jofph.2026.053.

Journal

Journal of Oral & Facial Pain and Headache

Publication type

research_article

Evidence level

4

Population

Patients diagnosed with vestibular migraine

Intervention

Quantitative pupillometry measurement