Neurological manifestations in children with hemoglobin SC (HbSC) disease remain insufficiently characterized, particularly regarding acute events. The aim of this study was to describe the spectrum and frequency of acute neurological events in a multicenter cohort of children with HbSC disease.
✦ The floor
Discussion
Signed responses from readers of the wire.
No actionable change for audiologists — this study addresses neurological events in a hematology/pediatric oncology population and has no direct audiology clinical implication.
Hemoglobin SC disease can cause sensorineural hearing loss (nerve-related hearing damage) as a complication, so a clearer picture of its neurological profile may indirectly inform audiologists monitoring at-risk pediatric patients.
- 01Hemoglobin SC disease is a sickle cell variant whose neurological manifestations are poorly characterized in existing literature.
- 02Multicenter retrospective design pools data across hospitals to describe acute neurological events in affected children.
- 03Published in Pediatric Blood & Cancer (PMID 42622377; DOI 10.1002/1545-5017.70605).
- 04Hearing loss is a recognized but secondary complication in sickle cell disorders; this study focuses on neurological events.
- 05Findings are descriptive; no intervention or treatment comparison is made.
Neurological manifestations of hemoglobin SC disease remain insufficiently described in children.
studysupported- PMID
- 42622377
- DOI
- 10.1002/1545-5017.70605.
- Journal
- Pediatric Blood & Cancer
- Publication type
- research_article
- Evidence level
- 4
- Population
- Children with hemoglobin SC disease experiencing acute neurological events
- Intervention
- Characterization of acute neurological events in hemoglobin SC disease
Primary outcomes
Type and frequency of acute neurological events in children with hemoglobin SC disease; Clinical features distinguishing neurological presentations in this population