Tinnitus

✦ Clinical Takeaway ✦

No actionable change — a Nature Reviews primer is a reference and educational resource, not a source of new clinical evidence requiring immediate practice revision.

✦ Why It Matters ✦

A Nature Reviews Disease Primers entry on tinnitus serves as a global scientific reference point that will shape research priorities and educational curricula for years.

✦ Key Points ✦

01Published in Nature Reviews Disease Primers (DOI: 10.1038/s41572-026-00713-x).
02Primers in this journal are authoritative, expert-authored overviews of a disease area.
03No abstract was available; full content details are limited.
04Likely covers epidemiology, pathophysiology, diagnosis, and management of tinnitus.
05High citation potential given the journal's international readership.

✦ Research metadata ✦

PMID: 42168184
DOI: 10.1038/s41572-026-00713-x.
Journal: Nature Reviews Disease Primers
Publication type: review
Evidence level: 5

Primary outcomes

Comprehensive overview of tinnitus epidemiology, mechanisms, diagnosis, and management

✦ Related stories ✦

PubMed·Journal article·Tinnitus·9d ago

Can Tinnitus Cause Speech-in-Noise Deficits?

alone; await full-text review before changing how you counsel tinnitus patients about speech-in-noise difficulties.

PubMed·Clinical trial·Tinnitus·3w ago

Mobile Application as a Digital Therapeutic for Chronic Tinnitus: A Randomized Clinical Trial

If the app demonstrated significant efficacy, audiologists managing chronic tinnitus patients should consider whether a CBT-based digital therapeutic could complement or extend clinic-based tinnitus management — specific outcome data from the trial should be reviewed before...

PubMed·Journal article·Tinnitus·2w ago

EEG Spectral Analysis of Tinnitus Sound Therapy: Meta-Analysis

This meta-analysis provides neurophysiological evidence supporting sound therapy's effect on brain activity in chronic tinnitus, but clinicians should interpret EEG outcomes cautiously as surrogate markers until they are linked to validated patient-reported symptom improvement.

PubMed·Journal article·Tinnitus·2w ago

Analysis of Depression and Anxiety in Patients With Tinnitus: A Focus on Specific Age Groups and Sex-Related Differences

Audiologists should routinely screen working-age tinnitus patients for anxiety, depression, and insomnia, and interpret results with awareness that age and sex influence these comorbidities.

PubMed·Journal article·Tinnitus·7d ago

Exploring the Link Between Tinnitus and Loudness Intolerance

Clinicians should routinely screen for loudness intolerance in patients presenting with tinnitus, given their frequent co-occurrence; however, the study's specific findings must be reviewed before adjusting formal assessment protocols.

PubMed·Journal article·Tinnitus·8d ago

Neuromodulation for Subjective Tinnitus: A Systematic Review and Meta-Analysis of Randomized Trials

This meta-analysis of RCTs is the strongest available evidence class on neuromodulation for tinnitus; clinicians should review effect sizes and safety data before recommending these treatments, but current evidence likely does not yet support routine adoption.

PubMed·Journal article·Tinnitus·2w ago

A dilated mastoid emissary vein as a potential cause of pulsatile tinnitus

Clinicians evaluating idiopathic pulsatile tinnitus should consider dilated mastoid emissary vein as a vascular cause; imaging review specifically targeting this structure may improve diagnostic yield in otherwise unexplained cases.

PubMed·Journal article·Tinnitus·3w ago

Tinnitus Trends in Young Adults: Prevalence and Duration from 2008 to 2023

Rising tinnitus prevalence and duration in young adults warrant earlier screening and counseling in clinical practice, particularly for patients with recreational noise exposure histories.