: Vestibular migraine (VM) is a common cause of episodic vertigo, yet its diagnosis remains primarily clinical and is often complicated by the absence of reliable objective biomarkers. Pupillary nystagmus, reflecting spontaneous oscillations of pupil diameter, has been proposed as a potential clinical sign of VM, but its quantitative characterization remains limited....
Pupillary nystagmus measured by pupillometry shows potential as an objective marker for vestibular migraine, but the technique is not yet validated for routine clinical use; no immediate practice change is warranted.
Vestibular migraine is one of the most common causes of episodic vertigo yet remains a diagnosis of exclusion; an objective biomarker would be a significant step toward earlier and more reliable diagnosis.
- 01Pupillary nystagmus (rhythmic eye-pupil movement) was quantified using infrared pupillometry in vestibular migraine patients.
- 02The study positions pupillary nystagmus as a potential objective neuro-otological biomarker.
- 03Vestibular migraine diagnosis currently relies heavily on symptom history with no gold-standard objective test.
- 04Quantitative pupillometry is a non-invasive measurement technique.
- 05Validation in larger, controlled cohorts is needed before clinical adoption.
Pupillary nystagmus can serve as an objective neuro-otological biomarker for vestibular migraine.
studypartially supportedQuantitative pupillometry can reliably detect and measure pupillary nystagmus in vestibular migraine patients.
studypartially supported- PMID
- 42345619
- DOI
- 10.3390/audiolres16030079.
- Journal
- Audiology Research
- Publication type
- research_article
- Evidence level
- 4
- Population
- Patients diagnosed with vestibular migraine
- Intervention
- Quantitative pupillometry to measure pupillary nystagmus
Primary outcomes
Presence and quantitative characteristics of pupillary nystagmus; Diagnostic accuracy as a biomarker for vestibular migraine