To present a case of tumor-to-tumor metastasis involving vestibular schwannoma and review previously reported cases, with focus on histopathologic and immunohistochemical characteristics. PATIENTS: Case report of a 55-year-old female with a history of invasive ductal breast carcinoma who presented with unilateral hearing loss and gait disturbance.
No actionable change for routine practice; clinicians should be aware that unusual growth or symptoms in a known vestibular schwannoma could, very rarely, indicate a secondary metastatic deposit requiring broader oncologic workup.
Tumor-to-tumor metastasis involving vestibular schwannoma is exceedingly rare, and awareness of this entity may prevent misdiagnosis and guide appropriate pathologic evaluation in atypical cases.
- 01Tumor-to-tumor metastasis into a vestibular schwannoma is an exceptionally rare pathological finding.
- 02Histopathologic and immunohistochemical analysis is essential for confirming this diagnosis.
- 03A literature review contextualises the handful of previously reported cases worldwide.
- 04Clinicians should consider metastatic disease when a vestibular schwannoma behaves atypically.
- 05Published in Otology & Neurotology (MAO journal).
Tumor-to-tumor metastasis involving vestibular schwannoma is a rare but documented phenomenon.
studypartially supportedHistopathologic and immunohistochemical analysis can characterise tumor-to-tumor metastasis in vestibular schwannoma.
studysupported- PMID
- 42283164
- DOI
- 10.1097/MAO.0000000000004977.
- Journal
- Otology & Neurotology
- Publication type
- case_report
- Evidence level
- 4
- Population
- Individual patient(s) with vestibular schwannoma found to harbour tumor-to-tumor metastasis
- Intervention
- Histopathologic and immunohistochemical analysis of tumor-to-tumor metastasis in vestibular schwannoma
Primary outcomes
Histopathologic characterisation of metastatic deposits within vestibular schwannoma; Immunohistochemical profile of dual-tumor specimens