Stereotactic radiosurgery (SRS) is an established, minimally invasive treatment for vestibular schwannoma (VS). However, tumor control rates vary, and predictors of treatment failure remain debated. This study examines whether pre-treatment tumor volume (TV) predicts SRS outcome and explores the relationship between tumor size, Paddick Conformity Index (PCI), and long-term control.
Tumor volume alone is not a reliable predictor of stereotactic radiosurgery success for vestibular schwannoma; clinicians should consider this when counseling patients about radiosurgery outcomes, though treatment selection criteria require further refinement.
Clarifying volumetric predictors of radiosurgery outcomes for vestibular schwannoma has direct implications for patient selection and shared decision-making in a condition that straddles audiology and neuro-oncology.
- 01Published in Neuro-Oncology Advances; investigates volumetric predictors of stereotactic radiosurgery (SRS) outcomes in vestibular schwannoma.
- 02Identifies a 'volume-conformity paradox' — expected relationship between tumor volume and treatment success was not straightforward.
- 03Findings challenge simple volume-based patient selection criteria for SRS.
- 04Vestibular schwannomas are benign tumors affecting hearing, balance, and facial nerve function.
- 05Results may inform more nuanced pre-treatment planning and outcome prediction models.
Tumor volume does not straightforwardly predict success or failure of stereotactic radiosurgery in vestibular schwannoma.
studypartially supported- PMID
- 42325603
- DOI
- 10.1093/noajnl/vdag139.
- Journal
- Neuro-Oncology Advances
- Publication type
- research_article
- Evidence level
- 4
- Population
- Patients with vestibular schwannoma treated with stereotactic radiosurgery
- Intervention
- Stereotactic radiosurgery for vestibular schwannoma
Primary outcomes
Volumetric determinants of treatment success; Volumetric determinants of treatment failure