Audiological testing in individuals with common variable immunodeficiency (CVID) has shown that the inner ear is affected in this patient group. The study's objective was to investigate the vestibular system in the inner ear in individuals with CVID.
Audiologists and vestibular specialists should be aware that CVID patients may show inner-ear and balance abnormalities; consider vestibular screening as part of the workup for this population, though this single study is not yet sufficient to mandate a protocol change.
It highlights a previously underappreciated link between immune dysfunction and vestibular pathology, potentially expanding the scope of audiological assessment in immunodeficiency clinics.
- 01CVID is a primary immunodeficiency characterised by low antibody production and recurrent infections.
- 02Prior research suggested inner-ear involvement in CVID; this study systematically evaluates vestibular test results.
- 03Findings may support routine vestibular screening in CVID patient management.
- 04Published in a peer-reviewed otolaryngology journal (IAO, 2025).
- 05Study builds on a growing body of evidence linking immune-mediated mechanisms to inner-ear disorders.
Patients with CVID show abnormal vestibular test results consistent with inner-ear involvement.
studypartially supported- PMID
- 42378542
- DOI
- 10.5152/iao.2025.251958.
- Journal
- Journal of the International Advanced Otology
- Publication type
- research_article
- Evidence level
- 4
- Population
- Patients diagnosed with Common Variable Immunodeficiency (CVID)
- Intervention
- Vestibular function testing battery
Primary outcomes
Vestibular test result profiles in CVID patients; Prevalence of inner-ear abnormalities in CVID