Tinnitus is a complex auditory perceptual disorder often accompanied by neuroinflammatory responses and metabolic abnormalities. Increasing evidence suggests that persistent oxidative stress, together with its interactions with immune regulation and energy metabolism, contributes to the pathophysiology of tinnitus....
✦ Clinical Takeaway ✦
No actionable change for current clinical practice; findings are discovery-stage and require substantial validation before informing tinnitus drug development or treatment protocols.
✦ Why It Matters ✦
Identifying druggable molecular targets through genomic analysis could accelerate tinnitus pharmacotherapy research, an area with no FDA-approved treatments to date.
✦ Key Points ✦
- 01Multi-omics analysis links oxidative stress pathways to tinnitus pathology.
- 02