ETHNOPHARMACOLOGICAL RELEVANCE: Da Chuanxiong Formula (DCXF), composed of Ligusticum chuanxiong and Gastrodia elata, is a classical traditional Chinese medicine prescription historically used for headache disorders. However, its role in vestibular migraine (VM) remains unclear....
No actionable change — this is a preclinical animal study; findings cannot be applied to clinical vestibular migraine management until human trials are completed.
Identifying novel pharmacological targets (DRD2/TRPV1) for vestibular migraine may inspire future drug development relevant to a condition with limited treatment options.
- 01Da Chuanxiong Formula (traditional Chinese medicine) was delivered intranasally in an animal model.
- 02Treatment reduced vestibular migraine-like symptoms by modulating DRD2 and TRPV1 signaling pathways.
- 03Study is preclinical; results have not been tested in human patients.
- 04DRD2 (dopamine receptor) and TRPV1 (pain/heat sensor channel) are proposed as therapeutic targets.
- 05Findings are exploratory and require clinical validation before any practice change.
Intranasal Da Chuanxiong Formula alleviates vestibular migraine-like phenotypes in a preclinical model.
studypartially supportedThe mechanism of action involves modulation of DRD2/TRPV1-associated signaling.
studypartially supported- PMID
- 42144207
- DOI
- 10.1016/j.jep.2026.121871.
- Journal
- Journal of Ethnopharmacology
- Publication type
- research_article
- Evidence level
- 4
- Population
- Animal model of vestibular migraine-like phenotypes
- Intervention
- Intranasal Da Chuanxiong Formula (traditional Chinese herbal medicine)
- Comparator
- Vehicle control / untreated model animals
Primary outcomes
Reduction of vestibular migraine-like phenotypes; Modulation of DRD2/TRPV1-associated signaling pathways