Time-course profiling of behavioral phenotypes and Ywhah/ERK signaling expression within the vestibular region of the brainstem during motion sickness habituation

Motion sickness habituation represents a core neuroplastic model for investigating vestibular disorder adaptation, yet its brain-region-specific temporal molecular mechanisms remain poorly defined. Here, we adopted multi-brain-region proteomic screening combined with time-series molecular validation to characterize key molecular dynamics during motion sickness habituation....

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No actionable change — this is a basic-science animal study exploring molecular signaling during motion sickness habituation; findings are too preliminary to inform clinical vestibular practice.

Identifying the molecular timeline of vestibular adaptation in the brainstem could eventually point to drug or rehabilitation targets for patients with chronic motion sickness or vestibular dysfunction.

1. 01Study mapped behavioral and molecular changes over time during motion sickness habituation in an animal model.
2. 02Focus was on the vestibular brainstem region, a key hub for balance and motion processing.
3. 03Ywhah and ERK signaling proteins were profiled as potential mediators of neuroplastic (brain-rewiring) adaptation.
4. 04Region-specific temporal patterns suggest the brainstem adapts to repeated motion exposure through distinct molecular phases.
5. 05Findings are preclinical and not yet applicable to human clinical vestibular management.

PMID

42909253

DOI

10.3389/fnins.2026.1955920.

Journal

Frontiers in Neuroscience

Publication type

research_article

Evidence level

4

Population

Animal model subjects undergoing repeated motion exposure to induce and habituate motion sickness

Intervention

Repeated motion exposure to induce motion sickness habituation