Morphological phenotyping of genetically engineered or experimentally challenged mice is the first step in researching the causality of congenital malformations. Especially for spatially complex structures like the inner ear, this is challenging....
No actionable change for clinical audiologists — this is a foundational animal developmental biology reference dataset with no direct human clinical application at this stage.
Precise embryological reference data for the mouse membranous labyrinth will accelerate basic-science research into congenital inner ear malformations and may support future genetic and teratology studies.
- 01Stage-specific morphological reference data established for mouse inner ear from E9.5 to E14.5.
- 02C57BL/6N mouse strain used — a common genetic background in hearing research.
- 03Both metric (measurements) and descriptive data are provided for each developmental stage.
- 04Reference dataset designed to help identify inner ear malformations in experimental models.
- 05Published in Frontiers in Cell and Developmental Biology.
The established reference dataset can be used to identify morphological malformations of the membranous labyrinth in C57BL/6N mouse embryos.
studysupported- PMID
- 42148304
- DOI
- 10.3389/fcell.2026.1725738.
- Journal
- Frontiers in Cell and Developmental Biology
- Publication type
- research_article
- Evidence level
- na
- Population
- C57BL/6N mouse embryos at developmental stages E9.5 to E14.5
- Intervention
- Stage-specific morphometric and descriptive analysis of the membranous labyrinth
Primary outcomes
Metric reference data for membranous labyrinth development per embryonic stage; Descriptive morphological characterisation at each stage; Utility for identifying congenital inner ear malformations