Development of a multi-parameter MRI-based habitat radiomics model for differential diagnosis of vestibular schwannoma and meningioma in the cerebellopontine angle: a multi-center study

Vestibular schwannomas (VS) and meningiomas (MM) are the most common benign tumors in the cerebellopontine angle (CPA), often presenting with similar clinical symptoms. Accurate preoperative differentiation is essential for appropriate treatment planning....

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This multi-center radiomics model shows promise for non-invasive preoperative differentiation of vestibular schwannoma from meningioma in the cerebellopontine angle, but requires prospective validation before it can replace or meaningfully supplement current diagnostic workup.

Accurate preoperative tumor differentiation in the cerebellopontine angle directly influences surgical planning, approach, and patient counseling, and a validated MRI-based model could reduce reliance on intraoperative or histological confirmation.

1. 01Multi-center study developed an MRI habitat radiomics model to distinguish vestibular schwannoma from meningioma preoperatively.
2. 02Both tumors arise in the cerebellopontine angle and can look similar on conventional imaging, complicating diagnosis.
3. 03Habitat radiomics analyzes spatially distinct sub-regions within a tumor rather than treating it as a single entity.
4. 04Multi-center design improves generalizability compared to single-institution radiomics studies.
5. 05Clinical adoption awaits prospective external validation in routine diagnostic settings.

PMID

42928133

DOI

10.1186/s12885-026-16612-z.

Journal

BMC Cancer

Publication type

research_article

Evidence level

2b

Population

Patients with cerebellopontine angle tumors (vestibular schwannoma or meningioma) from multiple centers

Intervention

Multi-parameter MRI-based habitat radiomics model for tumor classification

Comparator

Conventional MRI diagnosis / histopathological confirmation