Systemic immune-inflammation index and prognostic nutritional index in vestibular migraine and Meniere's disease: a retrospective comparison with healthy controls

To investigate whether the systemic immune-inflammation index (SII) and prognostic nutritional index (PNI) differ among patients with vestibular migraine (VM), patients with Meniere's disease (MD), and healthy controls, and to examine their associations with annual vertigo attack frequency and dizziness-related disability.

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✦ The floor

Discussion

Signed responses from readers of the wire.

✦ Clinical Takeaway ✦

No actionable change — the systemic immune-inflammation and prognostic nutritional indices are not yet validated clinical tools for diagnosing or managing vestibular migraine or Meniere's disease.

✦ Why It Matters ✦

Identifying objective blood-based markers that differ between vestibular migraine and Meniere's disease could eventually aid in differential diagnosis, which is currently largely clinical and symptom-based.

✦ Key Points ✦

01Systemic immune-inflammation index (SII) and prognostic nutritional index (PNI) differed between vestibular migraine, Meniere's disease, and healthy controls.
02Retrospective design limits causal inference; results are exploratory.
03Suggests a potential role of systemic inflammation in both conditions.
04Could point toward future blood-test-assisted differential diagnosis of these overlapping disorders.
05Study is a retrospective comparison — larger prospective studies are needed.

✦ Claims & Evidence ✦

ClaimEvidenceSupport

SII and PNI values differ significantly between vestibular migraine, Meniere's disease, and healthy controls.

studypartially supported

Systemic inflammation and nutritional status may contribute to the pathophysiology of vestibular migraine and Meniere's disease.

studyunclear

✦ Research metadata ✦

PMID: 42747533
DOI: 10.1007/s00405-026-10635-9.
Journal: European Archives of Oto-Rhino-Laryngology
Publication type: research_article
Evidence level: 3
Population: Adults with vestibular migraine, adults with Meniere's disease, and healthy controls
Intervention: Measurement of systemic immune-inflammation index (SII) and prognostic nutritional index (PNI)
Comparator: Healthy controls

Primary outcomes

Differences in SII and PNI across vestibular migraine, Meniere's disease, and healthy control groups

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