Therapeutic Interventions for Genetic Hearing Loss: Inside the SKY-GJB2 Trial

Gene therapy is opening new possibilities for addressing the underlying causes of genetic hearing loss. Brian Taylor, AuD, is joined by Jodi Cook, PhD, CEO of Skylark Bio, and Alexa Kozak, AuD, to discuss emerging therapeutic interventions for inherited hearing loss, with a particular focus on GJB2-related hearing loss, commonly associated with the connexin 26 protein....

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PubMed·Journal article·Research (general)·3mo ago

Impaired speech-in-noise perception in individuals with a history of hearing symptoms after noise exposure

Audiologists should consider supplementing standard audiograms with speech-in-noise testing for patients reporting noise-exposure symptoms, as normal thresholds alone may miss clinically meaningful hearing dysfunction consistent with cochlear synaptopathy (hidden hearing loss).

PubMed·Journal article·Research (general)·5mo ago

Effects of Hearing Intervention on Cognitive Function in Patients with Presbycusis: A Systematic Review and Meta-Analysis

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PubMed·Journal article·Research (general)·4mo ago

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PubMed·Journal article·Research (general)·4d ago

Loneliness as a pathway linking hearing decline to cognitive aging: Longitudinal and genetic evidence

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PubMed·Journal article·Research (general)·4mo ago

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PubMed·Journal article·Research (general)·6w ago

Increased listening effort and decreased speech perception at high presentation sound levels in older hearing-impaired adult listeners

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PubMed·Clinical trial·Research (general)·6w ago

Effects of hearing intervention on blood-based biomarkers of neuroinflammation and neurodegeneration: a secondary analysis of the ACHIEVE randomised controlled trial

are secondary and exploratory — audiologists should not change practice based on these biomarker findings alone, but the study adds biological plausibility to hearing intervention as a potential tool for brain health preservation.

PubMed·Preprint·Research (general)·3mo ago

Older adults show overexaggerated and larger noise-related degradation in their neural tracking of speech

This finding suggests age-related declines in how the brain tracks speech in noise go beyond peripheral hearing loss; audiologists should be cautious attributing all speech-in-noise difficulty in older adults to the audiogram alone, though the preprint has not yet been...