CD4⁺ T cells are central regulators of neuroimmune responses, and their dysregulation is increasingly recognized as a pathogenic driver across multiple neurological disorders, including multiple sclerosis (MS), Alzheimer's disease (AD), Parkinson's disease (PD), ischemic stroke (IS), traumatic brain injury (TBI), central nervous system (CNS) infections, and stress-induced vestibular dysfunction....
✦ The floor
Discussion
Signed responses from readers of the wire.
No actionable change — this is a basic-science immunology review with no direct audiology or hearing-care clinical implications at this time.
Understanding how immune cells contribute to neural damage and repair could eventually inform research into immune-mediated hearing disorders such as autoimmune inner ear disease, but that link is not explored here.
- 01Review covers dual roles of CD4⁺ T cells: driving neural damage and promoting repair.
- 02Focus is on neurological disorders, primarily multiple sclerosis.
- 03Published in Molecular Neurobiology; categorised as a review article.
- 04No audiology-specific data or outcomes are presented.
- 05Findings are foundational science with no direct clinical guidance for audiologists.
- PMID
- 42611157
- DOI
- 10.1007/s12035-026-06138-7.
- Journal
- Molecular Neurobiology
- Publication type
- review
- Evidence level
- 5
- Population
- Neurological disorder patients and animal/in-vitro models reviewed across literature
- Intervention
- CD4⁺ T cell neuroimmune activity
Primary outcomes
Characterisation of CD4⁺ T cell roles in neural damage; Characterisation of CD4⁺ T cell roles in neural repair