The calcitonin gene-related peptide (CGRP) is a 37-amino acid neuropeptide belonging to the calcitonin family, discovered as a product of alternative splicing of the calcitonin gene. CGRP has emerged as a pleiotropic signaling molecule with widespread distribution in the central and peripheral nervous systems, particularly within primary sensory neurons....
No actionable change for audiology practice at this time; the auditory and vestibular sections are background science, not clinical guidance.
Understanding CGRP's role in the auditory and vestibular systems may open future therapeutic targets for conditions such as vestibular migraine and Ménière's disease.
- 01CGRP is a neuropeptide with widespread signaling roles across cardiovascular, pain, and sensory systems.
- 02The review covers CGRP's presence and potential function in auditory and vestibular tissues.
- 03CGRP-targeting therapies (e.g., anti-migraine monoclonal antibodies) are already in clinical use for migraine.
- 04Pathophysiological roles in inner ear disorders such as vestibular migraine are discussed but remain speculative.
- 05Comprehensive scope spans basic biology through therapeutic applications across multiple organ systems.
CGRP plays a signaling role in auditory and vestibular contexts.
studypartially supportedCGRP-targeting therapies have established therapeutic applications (e.g., migraine treatment).
guidelinesupported- PMID
- 42278498
- DOI
- 10.3390/ijms27114973.
- Journal
- International Journal of Molecular Sciences
- Publication type
- review
- Evidence level
- 1a
- Population
- Not applicable — narrative/comprehensive review of existing literature
- Intervention
- CGRP biology and therapeutic targeting
Primary outcomes
Characterisation of CGRP signaling pathways; Pathophysiological roles across organ systems including auditory and vestibular; Therapeutic applications of CGRP-targeting agents