Vestibular migraine (VM) is a vestibular disorder characterized by recurrent episodes of vertigo, frequently accompanied by headache, nausea, and vomiting, which substantially reduce patients' quality of life. The pathogenesis of VM remains incompletely understood. Current studies mainly focus on ion channel dysfunction, trigeminovascular mechanisms, and genetic susceptibility....
✦ The floor
Discussion
Signed responses from readers of the wire.
No actionable change — this is a mechanistic review; findings are pre-clinical and do not yet translate to clinical vestibular migraine management.
Elucidating glial cell crosstalk in vestibular migraine central sensitization may eventually open new therapeutic targets for a poorly understood and undertreated disorder.
- 01Reviews microglia-astrocyte signaling as a driver of central sensitization in vestibular migraine.
- 02Central sensitization is when the brain becomes hypersensitive and amplifies pain and dizziness signals.
- 03No current clinical interventions directly targeting this pathway are discussed.
- 04Findings are theoretical/mechanistic and not yet tested in clinical trials.
- 05May inform future drug development targeting neuroinflammatory pathways.
Microglia-astrocyte signal crosstalk contributes to central sensitization in vestibular migraine.
studypartially supported- PMID
- 42996790
- DOI
- 10.3389/fnins.2026.1844932.
- Journal
- Frontiers in Neuroscience
- Publication type
- review
- Evidence level
- 5
- Population
- Not applicable — narrative/mechanistic review of preclinical and clinical literature on vestibular migraine
- Intervention
- Microglia-astrocyte signaling crosstalk (mechanistic review)
Primary outcomes
Characterization of glial crosstalk mechanisms in central sensitization; Identification of potential therapeutic targets for vestibular migraine