Fabry disease (FD) is a lysosomal storage disorder leading to α-galactosidase A deficiency and glycosphingolipid accumulation. Neurological manifestations of FD, such as central nervous system involvement, peripheral neuropathy, and vestibular dysfunction that results in postural and cognitive impairment, may predispose individuals to injuries....
Audiologists seeing patients with Fabry disease should be alert to co-occurring vestibular dysfunction as a fall and injury risk factor, supporting early vestibular assessment in this population.
Linking Fabry disease to elevated injury risk via vestibular dysfunction highlights audiology's role in multidisciplinary management of rare lysosomal storage disorders.
- 01Nationwide Taiwanese cohort study using population-based data on Fabry disease patients.
- 02Fabry disease patients showed significantly increased risk of injury compared to controls.
- 03Vestibular dysfunction was identified as one neurological contributor to injury risk.
- 04Findings support proactive vestibular screening in Fabry disease management.
- 05Published in the International Journal of Medical Sciences.
Patients with Fabry disease face an increased risk of injury compared to the general population.
studysupportedVestibular dysfunction is a neurological contributor to elevated injury risk in Fabry disease.
studypartially supported- PMID
- 42328111
- DOI
- 10.7150/ijms.120352.
- Journal
- International Journal of Medical Sciences
- Publication type
- research_article
- Evidence level
- 2b
- Population
- Patients with Fabry disease in Taiwan, nationwide population-based cohort
- Intervention
- Fabry disease diagnosis (exposure)
- Comparator
- General population without Fabry disease
Primary outcomes
Risk of injury (incidence); Neurological manifestations including vestibular dysfunction as mediating factors