The vestibular system is crucial for our sense of balance, for detecting head movements, and for regulating gaze and posture. There are five vestibular organs located inside the temporal bone, including two otolith organs (utricle and saccule), which detect linear movement, and three cristae (lateral/horizontal, anterior, and posterior), which detect rotational movement....
✦ The floor
Discussion
Signed responses from readers of the wire.
No actionable change — this is a laboratory methods paper for mouse vestibular tissue; it has no direct clinical application at this time.
Standardized, reproducible dissection and quantification methods for mouse vestibular ganglia will accelerate basic science research into balance disorders, ototoxicity, and potential regenerative therapies.
- 01Describes a whole-mount dissection protocol for the mouse vestibular complex.
- 02Provides a validated method for counting vestibular ganglion neurons.
- 03Intended as a reproducible research tool for inner ear science.
- 04Published in a methods-focused journal (JoVE), emphasizing protocol standardization.
- 05No direct clinical or patient-care implications at present.
The described whole-mount dissection protocol enables reliable quantification of vestibular ganglion neurons in mice.
studysupported- PMID
- 42872769
- DOI
- 10.3791/72562.
- Journal
- Journal of Visualized Experiments (JoVE)
- Publication type
- research_article
- Evidence level
- na
- Population
- Mouse vestibular complex (animal model)
- Intervention
- Whole-mount dissection of the vestibular complex and neuron quantification protocol
Primary outcomes
Reproducibility of whole-mount vestibular complex dissection; Accuracy of vestibular ganglion neuron quantification