Persistent postural-perceptual dizziness (PPPD) is a chronic vestibular disorder lacking objective tools for monitoring disease activity. Quantitative electroencephalography (qEEG) has identified cortical hyperexcitability in migraine, but whether analogous patterns exist in PPPD and reverse with treatment is unknown....
✦ The floor
Discussion
Signed responses from readers of the wire.
No actionable clinical change yet — qEEG high beta activity is a promising objective biomarker for PPPD severity, but findings need replication in larger samples before influencing clinical assessment protocols.
Identifying an objective, measurable brain-based marker for PPPD could transform diagnosis and treatment monitoring of this difficult-to-quantify chronic vestibular disorder.
- 01Longitudinal qEEG study found high beta brain activity tracks disease severity in PPPD.
- 02High beta activity may serve as an objective biomarker for this chronic dizziness condition.
- 03Published in the Journal of Vestibular Research (PMID 42503621).
- 04PPPD is currently diagnosed clinically with no validated objective biomarker.
- 05Findings are preliminary and require replication in larger, controlled studies.
High beta EEG activity tracks disease state in persistent postural-perceptual dizziness (PPPD).
studypartially supportedHigh beta qEEG activity represents a potential objective biomarker for PPPD.
studypartially supported- PMID
- 42503621
- DOI
- 10.1177/09574271261471781.
- Journal
- Journal of Vestibular Research
- Publication type
- research_article
- Evidence level
- 2b
- Population
- Individuals with persistent postural-perceptual dizziness (PPPD)
- Intervention
- Longitudinal quantitative EEG monitoring of high beta activity
Primary outcomes
High beta EEG activity as a correlate of PPPD disease state over time