Utricular Compound Action Potential Thresholds to Pulsed Interaural Vibration in Guinea Pig, and Mechanical Tuning Curve Estimates in Mouse, Rat, Sheep, and Human

Determine thresholds of vestibular compound action potentials (vCAPs) evoked by pulsed interaural bone-conducted vibration (BCV) and estimate synchronization tuning curves for sinusoidal BCV and stapes vibration (SV) in multiple mammalian species.

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No actionable change — this is a basic science, multi-species study characterizing utricular physiology; findings may eventually inform bone-conducted vestibular evoked potential testing but have no immediate clinical application.

Understanding utricular response thresholds and mechanical tuning across species lays important groundwork for refining bone-conduction-based vestibular diagnostic tests in humans.

1. 01Utricular compound action potential (CAP) thresholds to pulsed interaural bone-conducted vibration were measured in guinea pigs.
2. 02Mechanical tuning curve estimates were derived across four species: mouse, rat, sheep, and human.
3. 03Multi-species comparison allows extrapolation toward human vestibular physiology.
4. 04Published in Journal of the Association for Research in Otolaryngology (JARO), 2026.
5. 05Findings are foundational/basic science with no immediate clinical translation.

PMID

42745105

DOI

10.1007/s10162-026-01070-y.

Journal

Journal of the Association for Research in Otolaryngology

Publication type

research_article

Evidence level

4

Population

Guinea pig, mouse, rat, sheep, and human inner ear preparations

Intervention

Pulsed interaural bone-conducted vibration applied to measure utricular compound action potentials

Comparator

Cross-species comparison (mouse, rat, sheep, human)