Inconsistencies in outcome measures used in randomized controlled trials (RCTs) in Menière's Disease (MD) make it challenging to compare trial results. A Core Outcome Set (COS) standardizes outcome measures across studies, improving comparability and enhancing data synthesis for stronger evidence in clinical trials.ObjectiveTo develop a consensus-based COS for MD trials by identifying the most clinically relevant...
✦ The floor
Discussion
Signed responses from readers of the wire.
No immediate change to clinical practice; however, audiologists and otologists involved in Menière's disease research should adopt the COSMED core outcome set when designing future trials to improve evidence comparability.
Standardizing outcome measurement in Menière's disease trials will reduce heterogeneity in the evidence base, making meta-analyses and clinical guideline development more reliable.
- 01COSMED study used two separate, two-round Delphi surveys to build consensus on core outcome domains for Menière's disease RCTs.
- 02Goal is to standardize what gets measured across trials to allow meaningful cross-study comparisons.
- 03Delphi methodology involved multiple expert stakeholder rounds to reach agreement.
- 04Addresses a recognized gap: inconsistent outcome reporting has hampered Menière's disease evidence synthesis.
- 05Published in a peer-reviewed otology/audiology journal; relevant to researchers and guideline developers.
Standardizing outcome domains for Menière's disease trials through a core outcome set will improve cross-trial comparability.
studysupported- PMID
- 42970718
- DOI
- 10.1177/09574271261502634.
- Journal
- Clinical Otolaryngology
- Publication type
- research_article
- Evidence level
- 5
- Population
- Expert stakeholders in Menière's disease research and clinical care
- Intervention
- Delphi consensus process to develop a core outcome set for Menière's disease trials
Primary outcomes
Agreed core outcome domains for Menière's disease RCTs; Agreed specific outcome measures within those domains