Migraine may involve neuroimmune-related mechanisms, but migraine-associated peripheral immune-cell states remain incompletely defined. We aimed to characterize peripheral blood immune remodeling in migraine at single-cell resolution. We reanalyzed PBMC single-cell RNA-sequencing dataset GSE269117, using migraine and vestibular migraine samples as the migraine group and healthy controls as controls....
✦ The floor
Discussion
Signed responses from readers of the wire.
No actionable change — this is early-stage mechanistic research on immune cell gene expression in migraine with no direct clinical or audiology practice implications.
Understanding the neuroimmune basis of migraine may eventually inform treatment of vestibular migraine, a condition routinely encountered in audiology and otoneurology clinics.
- 01Single-cell RNA sequencing was used to profile CD4 T-cells in peripheral blood of migraine patients.
- 02Immune cell gene expression patterns were found to differ between migraine patients and controls.
- 03Findings point to neuroimmune crosstalk as a potential mechanism in migraine pathophysiology.
- 04Study is mechanistic and does not test any treatment or clinical intervention.
- 05No direct hearing-health relevance; indirect relevance via vestibular migraine overlap.
Peripheral CD4 T-cells undergo transcriptional remodeling in migraine patients detectable by single-cell RNA sequencing.
studypartially supported- PMID
- 42618703
- DOI
- 10.1007/s12031-026-02589-8.
- Journal
- Journal of Molecular Neuroscience
- Publication type
- research_article
- Evidence level
- 4
- Population
- Patients with migraine and healthy controls
- Intervention
- Single-cell RNA sequencing profiling of peripheral blood CD4 T-cells
- Comparator
- Healthy controls
Primary outcomes
Transcriptional state of peripheral CD4 T-cell subpopulations in migraine vs. controls