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Isolated Vestibular Nucleus Infarction Presenting as Vestibular Pseudoneuritis Mimicking Acute Peripheral Vestibulopathy

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Discussion

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Clinical Takeaway

Isolated vestibular nucleus infarction can be clinically indistinguishable from acute peripheral vestibulopathy; clinicians should maintain a low threshold for urgent neuroimaging (MRI) in patients presenting with sudden vestibular syndrome, particularly when vascular risk factors are present.

Why It Matters

This case reinforces the diagnostic challenge of central versus peripheral vestibular disorders and highlights the risk of misattributing a potentially life-threatening brainstem stroke to a benign inner-ear condition.

Key Points
  1. 01A brainstem stroke isolated to the vestibular nucleus can perfectly mimic vestibular neuritis (peripheral vestibulopathy).
  2. 02This presentation is termed 'vestibular pseudoneuritis' — a central lesion wearing a peripheral disguise.
  3. 03Standard bedside tests may fail to differentiate central from peripheral causes in such cases.
  4. 04MRI with diffusion-weighted imaging is critical for accurate diagnosis in ambiguous acute vestibular syndrome.
  5. 05Misdiagnosis carries serious risk: central strokes require urgent management unlike benign peripheral conditions.
Claims & Evidence

Isolated vestibular nucleus infarction can clinically mimic acute peripheral vestibulopathy (vestibular pseudoneuritis).

studypartially supported

Bedside clinical findings alone may be insufficient to distinguish isolated vestibular nucleus infarction from peripheral vestibulopathy.

studypartially supported
Research metadata
PMID
42616961
DOI
10.4103/aian.aian_294_26.
Journal
Annals of Indian Academy of Neurology
Publication type
case_report
Evidence level
4
Sample size
1
Population
Single patient presenting with acute vestibular syndrome later diagnosed as brainstem (vestibular nucleus) infarction
Intervention
Neuroimaging (MRI with diffusion-weighted imaging) for diagnosis of acute vestibular syndrome

Primary outcomes

Clinical and radiological characterisation of isolated vestibular nucleus infarction mimicking peripheral vestibulopathy

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