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Neuroanatomical correlates of stroke-related dizziness and vertigo: secondary analysis from the INSPiRE-TMS trial

A dispatch from PubMed — filed

Dizziness and vertigo are common and debilitating neurological symptoms among patients visiting the emergency department (ED). Possibly because the symptoms are not captured by standard stroke severity tools such as the NIHSS (National Institutes of Health Stroke Scale), their network-level neuroanatomical correlates-particularly potential supratentorial contributions-remain incompletely characterized....

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✦ The floor

Discussion

Signed responses from readers of the wire.

Clinical Takeaway

No actionable change for audiologists; this secondary neurological analysis informs neurologists about stroke-related dizziness anatomy but does not alter current vestibular or audiology practice.

Why It Matters

Mapping the brain regions behind stroke-related dizziness could eventually improve triage and differentiation of central versus peripheral vestibular causes in emergency settings.

Key Points
  1. 01Secondary analysis of the INSPiRE-TMS stroke trial focused on dizziness and vertigo symptoms.
  2. 02Specific neuroanatomical (brain structure) correlates of post-stroke dizziness were identified.
  3. 03Data sourced from emergency department stroke presentations.
  4. 04Findings contribute to understanding central vestibular dysfunction after stroke.
  5. 05Results may support future neuroimaging-guided differentiation of dizziness causes.
Claims & Evidence

Specific neuroanatomical regions are associated with dizziness and vertigo symptoms in stroke patients presenting to the emergency department.

studypartially supported
Research metadata
PMID
42584697
DOI
10.1007/s00415-026-14033-3.
Journal
Journal of Neurology
Publication type
research_article
Evidence level
3
Population
Stroke patients presenting to the emergency department with dizziness or vertigo, drawn from the INSPiRE-TMS trial
Intervention
Neuroanatomical lesion mapping in stroke patients with dizziness/vertigo
Comparator
Stroke patients without dizziness or vertigo

Primary outcomes

Neuroanatomical correlates associated with dizziness; Neuroanatomical correlates associated with vertigo

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