Mal de débarquement syndrome (MdDS) is a chronic vestibular disorder of non-spinning vertigo, with various somatic, cognitive, and affective symptoms. The manifestation of MdDS is often only subjective, and different symptoms are variably emphasized when patients appraise the severity of their illness....
No actionable clinical change yet; this is an exploratory or framework paper on personalized medicine for MdDS — a rare vestibular condition — and clinicians should monitor for follow-up trials before adjusting management.
MdDS remains poorly understood and difficult to treat; a personalized medicine framework could open new pathways for this underserved patient population.
- 01Study addresses mal de débarquement syndrome (MdDS), a chronic vestibular disorder causing persistent rocking/swaying.
- 02Explores personalized medicine approaches based on somatic, cognitive, and affective symptom profiles.
- 03Published in Frontiers in Neurology (doi: 10.3389/fneur.2026.1824869).
- 04MdDS is rare and lacks established, evidence-based treatment protocols.
- 05Findings may inform future stratified or individualized treatment trials.
Personalized medicine approaches can be applied to improve outcomes in mal de débarquement syndrome.
studypartially supportedMdDS presents with non-spinning vertigo and associated somatic, cognitive, and affective symptoms.
guidelinesupported- PMID
- 42440785
- DOI
- 10.3389/fneur.2026.1824869.
- Journal
- Frontiers in Neurology
- Publication type
- review
- Evidence level
- 5
- Population
- Patients with mal de débarquement syndrome
- Intervention
- Personalized medicine approaches for MdDS
Primary outcomes
Identification of symptom-based subgroups suitable for personalized treatment; Framework for individualized MdDS management