Effective nasal drug delivery requires an understanding of the factors that govern spray performance and regional nasal deposition. This study evaluated the effects of inspiratory flow, formulation viscosity, and device configuration on spray characteristics and regional nasal deposition....
✦ Clinical Takeaway ✦
No actionable change — this pharmaceutical study on nasal drug delivery has no direct application to audiology clinical practice.
✦ Why It Matters ✦
This article has no meaningful relevance to audiology; it addresses nasal drug deposition physics and device engineering, not hearing health.
✦ Key Points ✦
- 01Compares pressure-swirl versus soft mist nasal spray devices for regional drug deposition.
- 02Inspiratory flow rate is tested as a variable affecting deposition patterns.
- 03Published in International Journal of Pharmaceutics (2026).
- 04Relevant to ENT pharmacology and drug delivery, not audiology.
- 05No hearing-related outcomes measured.
✦ Research metadata ✦
- PMID
- 42208825
- DOI
- 10.1016/j.ijpharm.2026.126991.
- Journal
- International Journal of Pharmaceutics
- Publication type
- research_article
- Evidence level
- na
- Population
- Laboratory/device testing (nasal spray devices)
- Intervention
- Soft mist nasal spray device
- Comparator
- Pressure-swirl nasal spray device
Primary outcomes
Regional nasal drug deposition; Effect of inspiratory flow rate on deposition pattern