The vestibular system, a crucial sensorimotor apparatus for balance and spatial orientation, is regulated by neurotransmitters. Despite its essential function, the intricacies of neurotransmission within this system, particularly regarding monoamine neurotransmitters, remain not fully explained....
No actionable change at this time — this is a mechanistic review; clinical translation of monoamine neurotransmitter research to vestibular disorder treatment remains exploratory and is not yet ready to guide prescribing or referral decisions.
Clarifying how monoamine neurotransmitters modulate vestibular function may open new pharmacological avenues for treating balance disorders, a common and underserved condition in audiology and neurology practice.
- 01Review covers monoamine neurotransmitters (dopamine, serotonin, norepinephrine, histamine) and their roles in vestibular function.
- 02Evidence suggests monoaminergic systems influence balance, spatial orientation, and vestibular compensation.
- 03Findings are mechanistic; direct clinical applications are not yet established.
- 04Published in iScience (2026); no original data — synthesises existing literature.
- 05May inform future pharmacological research targeting vestibular disorders.
Monoamine neurotransmitters play a regulatory role in vestibular system function, balance, and spatial orientation.
studypartially supportedCurrent evidence supports monoaminergic involvement in vestibular disorders.
studypartially supported- PMID
- 42389603
- DOI
- 10.1016/j.isci.2026.116401.
- Journal
- iScience
- Publication type
- review
- Evidence level
- na
- Population
- Patients with vestibular disorders (reviewed across existing literature)
- Intervention
- Review of monoamine neurotransmitter systems (dopamine, serotonin, norepinephrine, histamine) in vestibular regulation
Primary outcomes
Role of monoamine neurotransmitters in vestibular function; Evidence linking monoaminergic systems to balance and spatial orientation disorders