In motor tasks with repetitive trials, motor vigor varies substantially from trial to trial in people with Parkinson's disease (PD). A key question is whether neural variability reflects behavioral variability or whether additional variability emerges as the neural signal is translated into movement. We aimed to identify a vigor-related neural network that could provide a candidate target for brain stimulation.
✦ The floor
Discussion
Signed responses from readers of the wire.
No actionable change — this is early-stage neuroscience research on motor control networks in Parkinson's disease with no direct audiology or hearing-care application.
Identifying a consistent brain network linked to motor variability in Parkinson's disease could eventually refine brain stimulation therapies, though implications for audiology practice are currently absent.
- 01Study maps a "vigor network" governing movement speed and energy consistency in Parkinson's disease.
- 02Trial-to-trial motor variability was used as a key measure to characterize the network.
- 03Network may serve as a stable target for brain stimulation interventions.
- 04Findings are relevant to neurology and movement disorders, not directly to audiology.
- 05Published in Frontiers in Human Neuroscience.
A consistent vigor network exists in Parkinson's disease that can be identified across patients.
studypartially supportedThis vigor network is a potential target for brain stimulation therapies in Parkinson's disease.
studyunclear- PMID
- 42877181
- DOI
- 10.3389/fnhum.2026.1928519.
- Journal
- Frontiers in Human Neuroscience
- Publication type
- research_article
- Evidence level
- 2b
- Population
- Patients with Parkinson's disease
- Intervention
- Characterization of a vigor network using trial-to-trial motor variability analysis
Primary outcomes
Consistency of vigor network topology across patients; Trial-to-trial motor variability