Vestibular disorders such as vestibular migraine (VM) and Menière's disease (MD) involve complex interactions between inflammation and neural circuit dysfunction. Emerging evidence highlights neuroimmune crosstalk as a unifying pathophysiological framework....
✦ The floor
Discussion
Signed responses from readers of the wire.
No immediate actionable change for clinical practice; this mechanistic review provides foundational science that may inform future drug targets for vestibular disorders but does not yet translate to treatment changes.
Elucidating neuroimmune mechanisms in vestibular disorders like Menière's disease and vestibular migraine could open new pharmacological treatment avenues and reframe these conditions as neuroinflammatory diseases.
- 01Reviews how immune and nervous system interactions drive vestibular disorder pathology.
- 02Focuses on vestibular migraine and Menière's disease as primary conditions of interest.
- 03Inflammation is linked to dysfunction in neural circuits controlling balance.
- 04Neuroimmune crosstalk identified as a potential therapeutic target.
- 05Primarily mechanistic; clinical translation is not yet established.
Neuroimmune crosstalk involving inflammatory pathways contributes to neural circuit dysfunction in vestibular disorders.
studypartially supportedVestibular migraine and Menière's disease share neuroimmune mechanisms that may represent common therapeutic targets.
opinionunclear- PMID
- 42852636
- DOI
- 10.3892/ijmm.2026.6009.
- Journal
- International Journal of Molecular Medicine
- Publication type
- review
- Evidence level
- 5
- Population
- Patients with vestibular disorders including vestibular migraine and Menière's disease
- Intervention
- Review of neuroimmune crosstalk mechanisms in vestibular disorders
Primary outcomes
Characterization of neuroimmune mechanisms in vestibular disorders; Identification of inflammatory pathways linked to neural circuit dysfunction