Presbycusis, or age-related hearing loss (ARHL), is a multifactorial disorder characterized by a gradual, bilateral sensorineural decline in hearing sensitivity, predominantly affecting high-frequency sounds. It is one of the most common chronic conditions in the aging population and represents a major public health concern due to its high prevalence and progressive nature....
This is a foundational science review; no actionable change to current clinical practice is indicated, but it informs understanding of why hearing loss progresses with age and may guide future therapeutic targets.
A multi-omics perspective on presbycusis could accelerate the identification of drug targets and genetic risk factors, laying groundwork for future preventive or therapeutic interventions for age-related hearing loss.
- 01Presbycusis (age-related hearing loss) is a multifactorial condition driven by genetic, epigenetic, and molecular factors.
- 02Multi-omics approaches (genomics, transcriptomics, proteomics, metabolomics) are being applied to understand inner-ear ageing.
- 03The review synthesises current knowledge on bilateral sensorineural hearing decline across the lifespan.
- 04Identifying molecular pathways could point to future drug or gene therapy targets.
- 05No single genetic cause explains presbycusis; many interacting variants contribute.
Presbycusis results from multifactorial genetic and molecular mechanisms rather than a single cause.
studysupportedMulti-omics data can reveal novel molecular contributors to age-related sensorineural hearing decline.
studypartially supported- PMID
- 42345621
- DOI
- 10.3390/audiolres16030081.
- Journal
- Audiology Research
- Publication type
- review
- Evidence level
- 5
- Population
- Literature review; no direct patient population
- Intervention
- Genetic, molecular, and multi-omics analysis of presbycusis mechanisms
Primary outcomes
Identification of genetic and molecular contributors to presbycusis; Synthesis of multi-omics findings relevant to age-related hearing loss