Vestibular compensation relies on sensory reweighting, but whether repeated hypergravity training (HT) facilitates recovery after bilateral vestibular lesion (BVL) remains unclear. We investigated the effects of HT on motor function and dorsal root ganglion (DRG) transcriptomes in mice following BVL. Mice underwent sham surgery or BVL and were assigned to either HT (2 G, 60 min/day for 10 days) or no HT (NHT)....
✦ The floor
Discussion
Signed responses from readers of the wire.
No actionable change — findings are from an animal model; hypergravity training is not a viable clinical intervention for vestibular rehabilitation at this time.
Understanding how the nervous system reorganizes during vestibular compensation could eventually inform non-pharmacological rehabilitation strategies for patients with bilateral vestibular loss.
- 01Repeated hypergravity training accelerated vestibular compensation after bilateral vestibular lesion in an animal model.
- 02Compensation was associated with remodeling of dorsal root ganglia (nerve clusters near the spine involved in sensory processing).
- 03Published in Journal of Physiological Sciences.
- 04Study is preclinical; human applicability is unknown.
- 05Findings suggest somatosensory pathways may play a compensatory role when the vestibular system is damaged.
Repeated hypergravity training facilitates vestibular compensation after bilateral vestibular lesion.
studypartially supportedVestibular compensation from hypergravity training is associated with dorsal root ganglion remodeling.
studypartially supported- PMID
- 42727320
- DOI
- 10.1016/j.jphyss.2026.100100.
- Journal
- Journal of Physiological Sciences
- Publication type
- research_article
- Evidence level
- 4
- Population
- Animal model with bilateral vestibular lesion
- Intervention
- Repeated hypergravity training
- Comparator
- Non-hypergravity control condition
Primary outcomes
Degree of vestibular compensation; Dorsal root ganglion structural remodeling