Significance of Systemic Immune-Inflammation and Inflammatory Response Indices in Vestibular Neuritis

This study investigated the relationship between vestibular neuritis and various systemic inflammatory indices-namely, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI) and the clinical severity of vestibular neuritis.

✦ Clinical Takeaway ✦

Systemic inflammatory indices (NLR, PLR, etc.) show association with vestibular neuritis, but evidence is insufficient to recommend routine blood panel screening in clinical practice at this time.

✦ Why It Matters ✦

If validated, systemic inflammatory markers could provide a simple, low-cost blood-test tool to support diagnosis and prognosis of vestibular neuritis.

✦ Key Points ✦

01Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were investigated as markers of inflammation in vestibular neuritis.
02The study suggests systemic immune-inflammation indices are significantly associated with vestibular neuritis.
03These markers are derived from routine complete blood count tests, making them inexpensive and widely available.
04Study design details (sample size, controls) are not provided in the description, limiting assessment of robustness.
05Findings may inform future diagnostic or prognostic protocols for vestibular disorders.

✦ Claims & Evidence ✦

ClaimEvidenceSupport

Systemic inflammatory indices such as neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio are significantly associated with vestibular neuritis.

studypartially supported

✦ Research metadata ✦

PMID: 42403362
DOI: 10.1111/coa.70140.
Journal: Clinical Otolaryngology
Publication type: research_article
Evidence level: 3
Population: Patients diagnosed with vestibular neuritis
Intervention: Measurement of systemic immune-inflammation indices (NLR, PLR, and other inflammatory response markers)
Comparator: Healthy controls or patients without vestibular neuritis (implied)

Primary outcomes

Association between systemic inflammatory indices and vestibular neuritis diagnosis; Neutrophil-to-lymphocyte ratio values in vestibular neuritis patients; Platelet-to-lymphocyte ratio values in vestibular neuritis patients

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