ETHNOPHARMACOLOGICAL RELEVANCE: Wendan Decoction is a classical traditional Chinese medicine formula historically used for phlegm-related dizziness and vertigo. Recent studies have shown that Wendan Decoction can ameliorate experimental endolymphatic hydrops (EH), a characteristic pathological correlate of Ménière's disease....
✦ The floor
Discussion
Signed responses from readers of the wire.
No actionable change; this is preclinical (animal/model) research on a traditional herbal compound with no clinical trial data, and TMF cannot be recommended for managing Ménière's disease or endolymphatic hydrops at this stage.
Identifying molecular pathways like DUSP3/p38 MAPK/AQP2 that regulate endolymphatic fluid could eventually guide new pharmacological targets for Ménière's disease, for which treatment options remain limited.
- 01TMF, derived from traditional Chinese Wendan Decoction, reduced endolymphatic hydrops (inner-ear fluid excess) in a preclinical model.
- 02Mechanism involves modulation of the DUSP3/p38 MAPK/AQP2 signaling axis, which regulates water transport in the inner ear.
- 03AQP2 (aquaporin-2) is a water-channel protein; its dysregulation is implicated in fluid imbalance seen in Ménière's disease.
- 04Study is animal/model-based; no human clinical data are presented.
- 05Findings are hypothesis-generating and support further mechanistic and translational research.
TMF alleviates endolymphatic hydrops by modulating the DUSP3/p38 MAPK/AQP2 signaling axis.
studypartially supportedWendan Decoction-derived TMF represents a potential therapeutic avenue for Ménière's disease.
studyunsupported- PMID
- 42854858
- DOI
- 10.1016/j.jep.2026.122488.
- Journal
- Journal of Ethnopharmacology
- Publication type
- research_article
- Evidence level
- 4
- Population
- Preclinical model of endolymphatic hydrops (relevant to Ménière's disease)
- Intervention
- Wendan Decoction-derived TMF compound
Primary outcomes
Reduction of endolymphatic hydrops in preclinical model; Modulation of DUSP3/p38 MAPK/AQP2 signaling axis