Vestibulodynia is the most common subtype of vulvodynia and is characterized by persitent, contact-evoked pain localized to the vulvar vestibule. Increasing evidence supports a neuropathic pain mechanism in vestibulodynia, including vestibular hyperinnervation, neuroinflammation, and overexpression of the transient receptor potential vanilloid 1 receptor....
No actionable change for audiology practice — this trial addresses vulvodynia pain, which falls entirely outside the scope of audiology and vestibular audiology clinical care.
While vestibulodynia involves the term 'vestibul-', this study is unrelated to the vestibular (balance) system and has no relevance to the audiology field.
- 01Study evaluates topical resiniferatoxin, a potent TRPV1 agonist, for vestibulodynia.
- 02Vestibulodynia is a vulvar pain condition — not a vestibular (balance) disorder.
- 03Prospective observational design; no randomization or control group.
- 04This article is outside the scope of audiology, balance, or hearing science.
- 05Likely indexed in audiology feeds due to keyword overlap with 'vestibular' — not clinically relevant to audiologists.
Topical resiniferatoxin is a candidate treatment for vestibulodynia (contact-evoked vulvar pain).
studypartially supported- PMID
- 42434379
- DOI
- 10.1016/j.xagr.2026.100660.
- Journal
- AJOG Global Reports
- Publication type
- research_article
- Evidence level
- 4
- Population
- Patients with vestibulodynia (contact-evoked vulvar vestibule pain)
- Intervention
- Topical resiniferatoxin applied to the vulvar vestibule
Primary outcomes
Pain reduction with contact stimulation at the vulvar vestibule; Safety and tolerability of topical resiniferatoxin