The vestibular system contributes to postural control, eye movements, spatial perception, and autonomic regulation. Its dysfunction causes vertigo, nausea, postural instability, which gradually improve via central plasticity known as vestibular compensation....
✦ The floor
Discussion
Signed responses from readers of the wire.
This is an animal study validating a vestibular testing method in mice; no actionable change for clinical practice at this stage.
Establishing reliable animal models and testing methods for drug-induced vestibular dysfunction could accelerate preclinical research into ototoxicity and vestibular rehabilitation.
- 01Caloric testing was applied to mice with arsanilic acid-induced vestibular dysfunction.
- 02Arsanilic acid was used to chemically model vestibular damage in animals.
- 03Study published in Biochemical and Biophysical Reports (2026).
- 04Findings may help validate preclinical vestibular assessment tools.
- 05Results are not directly transferable to human clinical practice.
The caloric test can be used to assess vestibular function in mice with arsanilic acid-induced vestibular dysfunction.
studypartially supportedArsanilic acid induces measurable vestibular dysfunction in mice.
studysupported- PMID
- 42502276
- DOI
- 10.1016/j.bbrep.2026.102715.
- Journal
- Biochemical and Biophysical Reports
- Publication type
- research_article
- Evidence level
- 4
- Population
- Mice with arsanilic acid-induced vestibular dysfunction
- Intervention
- Caloric test for vestibular functional assessment
Primary outcomes
Vestibular function as measured by caloric test response in arsanilic acid-treated mice