VGLL-fused intraparenchymal schwannoma with EWSR1::VGLL1 fusion: integrated clinicopathological and molecular characterization

Intraparenchymal schwannomas are rare intracranial tumors confined to the brain parenchyma without connection to peripheral nerves. While conventional schwannomas are often associated with NF2 inactivation, the pathogenesis of intraparenchymal schwannomas remains poorly understood....

No actionable change for audiologists — this is a neuropathology case characterization of a rare intracranial tumor with only incidental overlap with audiology (schwannomas can affect hearing); molecular findings are for pathologists and neuro-oncologists.

Identifying distinct molecular signatures in rare schwannoma variants advances accurate tumor classification, which may eventually inform differential diagnosis in cases where schwannomas affect the auditory pathway.

1. 01Describes a rare intraparenchymal (inside brain tissue) schwannoma — distinct from the more common vestibular schwannoma.
2. 02The tumor carries a novel EWSR1::VGLL1 gene fusion, aiding molecular classification.
3. 03Integrated clinicopathological and molecular characterization was performed.
4. 04Findings are primarily relevant to neuropathology and neuro-oncology, not routine audiology practice.
5. 05Published as a molecular characterization study (doi: 10.1186/s40478-026-02355-2).

PMID

42351298

DOI

10.1186/s40478-026-02355-2.

Journal

Acta Neuropathologica Communications

Publication type

case_report

Evidence level

4

Population

Patient(s) with VGLL-fused intraparenchymal schwannoma confirmed by molecular analysis

Intervention

Clinicopathological and molecular characterization of tumor tissue